In clinical studies, sildenafil tablets have mainly been tested at doses of 25 mg, 50 mg and 100 mg. The usual sildenafil dosage at the start of treatment is 50 mg to help men get an erection. In clinical research, approximately 74 percent of men have benefited from erection improvements with this dose. This dose is generally recommended for patients who have mild or moderate erection difficulties. The majority of men, however, increase the dose to 100 mg for best results.
A research study was conducted to assess erection hardness and intercourse success rate of 50 mg compared with sildenafil 100 mg doses. Information from two placebo-controlled studies was used whereby patients with erectile dysfunction were given 50 mg to be taken before sexual activity.
Men who tolerated the medication well had their dose increased to 100 mg after 2 weeks. A primary measure that was used to determine results was the Erection Hardness Score (EHS). In addition, the men were asked whether they were able to achieve erections that lasted long enough for successful sexual intercourse.
The study found that patients who received the 100 mg dose had considerably higher EHS scores than the patients treated with 50 mg. It concluded that men who are unable to obtain completely rigid erections or successful sexual intercourse with 50 mg should be encouraged to use 100 mg. The following are recommended sildenafil dosage guidelines:
When it comes to erectile dysfunction medication, more does not always mean better. At higher doses, sildenafil side effects like headache, dizziness and indigestion are more likely to happen. The maximum approved daily sildenafil dosage is 100 mg so patients are advised to carefully adhere to this guideline. There have, however, been clinical reports of patients taking higher doses for the treatment of severe erectile dysfunction.
A clinical trial was conducted to assess the efficacy and tolerability of high doses of this treatment for erectile dysfunction. This was particularly for patients who did not respond well to the maximum recommended daily sildenafil dosage of 100 mg.
A total of 54 patients with an average age of 59.6 years and chronic erection difficulties were involved in the study. They were treated at home with increasing doses of this medication up to 200 mg until an optimal response was achieved or intolerable side effects happened. After 4 weeks of treatment, an assessment questionnaire called the International Index of Erectile Function (IIEF) and a general efficacy question were used to determine results.
A total of 4 patients responded to a sildenafil dosage of 150 mg and 9 responded to an average maximum dose of 200 mg. However, 63% of patients reported adverse effects at this high dose. Altogether, 4 of the 13 responders (31%) refused to continue taking the medication due to side effects.
The study concluded that 200 mg may be effective for 24.1% of patients who previously did not respond to 100 mg. However, this higher dose is restricted by a considerably high occurrence of unpleasant side effects and a discontinuation rate of 31%.
Although sildenafil starts working within as little as 12 minutes for some men, studies have found that most patients feel the effects after 27 minutes. To make sure it has enough time to become completely effective, it is generally recommended that this medication is taken 30-60 minutes before sexual activity.
It is also important to remember that food can affect the time to onset of effects of erectile dysfunction treatments like this. Taken on a full stomach or with high-fat food, the absorption rate can be affected, causing the onset of effects to be delayed.
In addition to food, grapefruit or grapefruit juice can affect the time it takes for this medication to start working. A clinical trial was conducted to assess the effects of grapefruit juice on the pharmacokinetics of sildenafil tablets. The pharmacokinetics of a medication refers to how it is absorbed, metabolised, distributed and ultimately eliminated from the body.
Altogether, 24 participants were involved in the research and they received 50 mg of this medication. Half of the participants were given 250 ml of grapefruit juice to drink one hour before taking the medication and again with the medication. The other half received the same amount of water to take at the same times. Concentrations of this medication in the bloodstream were established after taking the doses.
The results of the study showed that the consumption of grapefruit juice extended the duration of time to peak concentrations in the bloodstream. It prolonged it by an average of 0.75 hours to 1.13 hours. Although it increased the percentage of medication that entered the circulation of the patients (bioavailability), it delayed the onset of effects.
Therefore, it is advisable to avoid grapefruit juice as it is better to be prepared ahead of time. This will ensure that you benefit from the full effects of the medication before initiating intimacy with your partner.
There is a moderate interaction between Amlodipine and treatments for erectile dysfunction like this. Therefore, the concurrent use should be avoided or used with extra caution. PDE5 inhibitors increase the blood-lowering effects of antihypertensives. If antihypertensives are used in combination with erectile dysfunction treatments, patients are advised to take a low dose and avoid standing abruptly from a sitting position.
This medication can help men get an erection particularly when used in combination with healthy lifestyle choices. Food choices like the Mediterranean diet as well as exercise like pelvic floor exercises can help men get an erection and treat their ED long-term - together with short-term relief from medication.
In fact, all types of exercise are good for erectile function as exercise improves the body's ability to produce nitric oxide, or NO. This helps keep blood flowing efficiently throughout the body, including the penis.
When sexual stimulation happens, the penis fills with blood and this is what gives it the rigidity that is needed for sex. Common questions related to erectile function range from; what is sildenafil…and how does sildenafil work?... Online resources like FAQ sections and websites like ours will answer these fundamental queries.
Like exercise, this medication enhances NO levels in the body. This causes blood vessels to relax and expand, leading to increased blood flow, which can help men get an erection that is suitable for sex.
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