How does Sildenafil Work?

How does Sildenafil Work?

When sexual stimulation happens, a naturally-occurring chemical in the body called nitric oxide (NO) is released into the corpora cavernosa of the penis. The corpora cavernosa is the two spongy masses of tissue that extend the length of the penis. Thereafter, NO triggers the release of a specific enzyme that increases cyclic guanosine monophosphate (cGMP) levels.

An increase in cGMP is good for erectile function, as this chemical messenger causes blood vessels in the penis to relax and expand. This allows blood to flow effortlessly into the penis when there is sexual stimulation, resulting in a firm and sustainable erection.

Sildenafil citrate enhances the effect of NO by inhibiting another enzyme called phosphodiesterase type 5 (PDE5). PDE5 is responsible for a decline of cGMP and this is detrimental for erections as it causes them to subside. These effective ED pills, help men get an erection by inhibiting PDE5.

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How do I Take Sildenafil?

For best results, take sildenafil tablets about 30-60 minutes before you plan to initiate sexual activity. This medication should be swallowed whole with some water and it stays effective in the body for 4 to 6 hours. Therefore, there is plenty of time to get in the mood for sex without the need to rush.

Avoid taking this medication with a large meal or food that is high in fat. This can reduce the absorption rate, delaying the onset of effects. Also, avoid or limit alcohol consumption as this can interfere with the efficacy of this medication. The following helpful tips are useful to remember during treatment:

  • This medication does not induce an erection on its own.
  • These pills help men get an erection only if there is sexual stimulation.
  • If a 50 mg dose does not work, you may want to consider taking sildenafil 100 mg.
  • For some patients, it may not work the first time, but experts usually recommend trying this medication 4 to 6 times before considering another treatment.

How Long does Sildenafil Take to Work?

A common question - apart from what is sildenafil? - is how long does it take to start working? Once ingested, the strongest effects are generally felt within 30 minutes to 2.5 hours. Some men report achieving an erection within as little as 12 minutes and these patients are considered 'first responders'. However, on average, most men feel the effects after 27 minutes. So, the results tend to vary from one person to another.

A clinical trial took place to assess the onset of effect of sildenafil in the treatment of erectile dysfunction. In total, 17 participants in the study received 50 mg of this erectile dysfunction treatment or inert placebo pills so the effects could be compared. This was followed by visual sexual stimulation and the results were determined by using a device that measures the quality of erections. The outcomes were as follows:

  • Average time to onset of erections was 27 minutes
  • 71% of the men experienced erections within 30 minutes
  • 82% of the men responded within 45 minutes

In clinical studies, for most patients, these erectile dysfunction pills, help men get an erection that is suitable for sexual activity. The starting sildenafil dosage is usually 50 mg, however, most men increase it to 100 mg.

What Happens If You Take Too Much Sildenafil?

In general, this medication is regarded as a safe treatment that has been used by countless men worldwide, with no significant health problems. In clinical studies, Viagra pills help men get an erection regardless of whether erection difficulties are caused by physical or psychological factors. However, some men wonder if they will experience even better results if they increase the dose.

Although some men do benefit from a higher dose, it is generally unsafe for most patients to increase the dose as this increases the risk of sildenafil side effects. Adverse effects associated with higher doses include a drop in blood pressure. This can lead to unwanted effects like weakness, dizziness and nausea. Other adverse reactions caused by high doses include rapid breathing, blurry vision and difficulty concentrating.

Another risk associated with unusually high doses of erectile dysfunction treatments is priapism. This condition is characterised by an erection that lasts longer than 4 hours. It is usually not caused by sexual stimulation and it can happen if too much blood flows into the penis. Priapism is a rare side effect that may happen with an overdose of erectile dysfunction medication. Carefully adhering to usage and dosage instructions can prevent this adverse effect.

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Is Sildenafil as Good as Viagra?

Sildenafil is the generic version of Viagra, so it is commonly referred to as generic Viagra. Both generic Viagra and its brand-name counterpart are frequently used to treat erectile dysfunction. These medications contain the same active ingredients, however, they are produced by different pharmaceutical companies. Generic Viagra and the branded version are identical in the following ways:

  • Dosages or strength of the medications
  • Effectiveness or how well they work in the body
  • Their safety and side effect profiles are the same
  • How long they take to begin working
  • Both erectile dysfunction treatments have the same duration of effect

When the patent for Viagra reached its expiry date, companies other than the original manufacturer were given rights on its production. They use the same chemical formula and are required to prove bioequivalence to the regulatory authorities. This means the generic medication must work the same way in the body and have the same pharmacological properties.

The primary difference is that generic sildenafil citrate is much less expensive than Viagra. You can expect to pay as little as 10% to 20% for generic Viagra, as compared to standard costs of the brand product. Generic companies are able to sell their medications at lower prices, because regulations that govern the generic industry do not require them to repeat expensive clinical studies.

You can order the best erectile dysfunction medication simply by logging on to our website. We provide fast online access to affordable medications with the convenience of home delivery. All transactions are kept secure using Secure Sockets Layer (SSL) software which safely encrypts information. Buy sildenafil today and regain a satisfying sex life by treating ED effectively.


Visit to see our full range of Kamagra products or follow one of the handy links to the main treatment options for erectile dysfunction and other erection problems such as premature ejaculation!

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Author: John Sanderson

Author: John Sanderson

After graduating The University of Strathclyde with a master’s degree in English literature and creative writing, John has enjoyed a prolonged career as a content writer. Drawn to the medical industry early in his career John made his name researching, writing and blogging about the latest advancements in the medical industry. By focusing on pioneering techniques and medicines John established himself in the field of medical science. Read more about John.

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