Also known by the brand name Viagra, sildenafil was taken by more than 3,700 patients between the ages of 19-87, before this medication was released in 1998. It was administered to these patients during worldwide clinical trials to test the safety and efficacy of the medication. In total, more than 550 of study participants decided to continue long-term treatment for more than a year.
In these trials, only 2.5% of patients withdrew from the research due to sildenafil side effects. Placebo was also used in these clinical trials. This treatment does not help men get an erection, because it contains substances, which are designed to have no therapeutic value. For example, placebo may contain sugar or starch.
Researchers can compare the effects of placebo with the medication being tested. The discontinuation rate due to placebo was 2.3%, indicating an insignificant difference from the side effects caused by sildenafil tablets.
Overall, the incidence of sildenafil side effects increases with higher doses. For this reason, carefully adhering to dosage guidelines can help reduce or prevent adverse reactions. During pre-marketing clinical trials, the following are some of the most common side effects that were observed:
| Side effect | 25 mg dose | 50 mg dose | Sildenafil 100 mg |
| Headache | 16% | 21% | 28% |
| Flushing | 10% | 19% | 18% |
| Indigestion | 3% | 9% | 17% |
| Nasal congestion | 4% | 4% | 9% |
| Nausea | 2% | 3% | 3% |
The occurrence of sildenafil side effects can, however, vary slightly and clinical studies are conducted under different conditions. A postmarketing study took place to assess the side effect profile of this medication in clinical practice.
Altogether, 256 patients with erectile dysfunction were given varying doses of sildenafil tablets. They were asked in a detailed manner about the side effects they experienced. The results of the study showed the following:
The study found that all adverse effects were mild in nature and short-lived. A total of 31.6% of the patients experienced at least one side effect and no one discontinued the study due to the severity of side effects.
There was a notable correlation between the occurrence of side effects and a higher sildenafil dosage. The study confirmed that this medication can help men get an erection and it is well tolerated in the treatment of erectile dysfunction.
Overall, reviews of this medication have shown positive results for patients with mild to severe erectile dysfunction. Sildenafil is possibly the best erectile dysfunction medication on the market, as it has been shown to help men get an erection and improve the frequency, hardness and duration of erections - with very high success rates.
The effects generally allow patients the ability to get and keep an erection that is adequate for sexual activity. This medication has been shown to improve the quality of life and sexual well-being for both patients and their sexual partners.
Like most medicines, some people may be hypersensitive to this treatment for erectile dysfunction. In clinical studies, allergic reactions have been extremely rare. The symptoms of a mild allergic reaction include itchiness and a skin rash. More severe reactions include swelling under the skin, lips, hands or feet as well as the mouth, tongue or throat.
Hypotension (low blood pressure) is another rare side effect of this medication. In fact, in clinical studies, less than 2% of study participants experienced this adverse effect. Nevertheless, a sudden drop in blood pressure can be unsafe, particularly if you are currently taking certain medications. These medications include riociguat, nitrates and nitric oxide donors like amyl nitrite so the concurrent use should be avoided.
Certain underlying health issues tend to increase the risk of uncommon side effects. For this reason, it is advisable to avoid erectile dysfunction treatments like PDE5 inhibitors if you have any of the following pre-existing health conditions:
What is sildenafil like in respect of duration of side effects? In general, mild side effects can be easily managed at home and they tend to go away within a few hours of taking a dose. Often, lying down and taking a rest allows enough time for side effects like headaches, dizziness or flushing to pass. Switching off any bright lights and avoiding the use of alcohol can help expedite the recovery of mild or moderate side effects.
There are ways to avoid, or at least cope, with common sildenafil side effects. The following list gives advice on managing these adverse effects:
Avoiding grapefruit and grapefruit products may help prevent side effects. Grapefruit increases concentrations of this medication in the bloodstream, making sildenafil side effects more likely to happen.
Linked to side effects, another frequent question that gets asked is how does sildenafil work? This medication can help men get an erection by boosting nitric oxide levels in the body. This natural chemical works with other enzymes in the body to relax and open blood vessels. As a result, blood flows more readily into the penis, resulting in a satisfactory erection. You can buy sildenafil at cost-effective prices and expect premium-quality medication that is well-tolerated, delivered in only a few working days.
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